Cryptic crossword clue
Ability to reason at the heart of MI6 12

The most common and most likely answer to this crossword clue is the 12 letter word INTELLIGENCE

I've seen this crossword clue in The Times
I
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Buddy explains!

The straight part
We know that "Ability to reason" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ability to reason = intelligence.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTELLIGENCE mean?

INTELLIGENCE noun
  1. Capacity of mind, especially to understand principles, truths, facts or meanings, acquire knowledge, and apply it to practice; the ability to comprehend and learn.
  2. An entity that has such capacities.
  3. Information, usually secret, about the enemy or about hostile activities.
  4. A political or military department, agency or unit designed to gather information, usually secret, about the enemy or about hostile activities.
  5. Acquaintance; intercourse; familiarity.

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