The most common and most likely answer to this crossword clue is the 4 plus 2 letter word TAKE UP
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Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does TAKE UP mean?
TAKE UP noun- The act of taking something up, by tightening, absorption, or reeling in.
- (machinery) That which takes up or tightens; specifically, a device in a sewing machine or loom for drawing up the slack thread as the needle rises, in completing a stitch.
- Acceptance (of a proposal, offer, request, etc.).