Cryptic crossword clue
Acclaimed American oddball in a university 10

The most common and most likely answer to this crossword clue is the 10 letter word ACADEMICAL

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Buddy explains!

The straight part
We know that "in a university" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case in a university = academical.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACADEMICAL mean?

ACADEMICAL noun
  1. Academic dress, consisting of a cap and gown.
ACADEMICAL adjective
  1. Belonging to the school of Plato; believing in Plato's philosophy; sceptical .
  2. Pertaining to a university or other form of higher education.

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