Cryptic crossword clue
Acclimatise to one-time melody 6

The most common and most likely answer to this crossword clue is the 6 letter word ATTUNE

I've seen this crossword clue in Financial Times
A
T
T
U
N
E


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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ATTUNE mean?

ATTUNE verb
  1. To bring into musical accord.
  2. To tune (an instrument).
  3. To bring into harmony or accord.

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