Cryptic crossword clue
Acid converter Sam and Ian adapted to penetrate Jock’s through passage 12

The most common and most likely answer to this crossword clue is the 12 letter word TRANSAMINASE

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Buddy explains!

The straight part
We know that "Acid converter" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case acid converter = transaminase.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRANSAMINASE mean?

TRANSAMINASE noun
  1. Any of a group of enzymes that catalyze transamination.

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