Cryptic crossword clue
Act four sits unwell with outspoken opponents 9

The most common and most likely answer to this crossword clue is the 9 letter word ACTIVISTS

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ACTIVISTS mean?

ACTIVISTS noun
  1. One who is politically active in the role of a citizen; especially, one who campaigns for change.
  2. One who is conspicuously active in carrying out any occupational or professional functions.

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