The most common and most likely answer to this crossword clue is the 2 plus 4 plus 6 letter word AT ROCK BOTTOM
A
T
R
O
C
K
B
O
T
T
O
M
Buddy explains!
The straight part
We know that "as low as you can" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case as low as you can = at rock bottom.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.