Cryptic crossword clue
Actor Nigel changes set for a new scene? 10

The most common and most likely answer to this crossword clue is the 10 letter word RELOCATING

I've seen this crossword clue in The Daily Telegraph
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Buddy explains!

The straight part
We know that "set for a new scene" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case set for a new scene = relocating.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does RELOCATING mean?

RELOCATING verb
  1. To move (something) from one place to another.
  2. To change one's domicile or place of business.

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