The most common and most likely answer to this crossword clue is the 6 letter word SCROTA
I've seen this crossword clue in Financial Times
S
C
R
O
T
A
Buddy explains!
The straight part
We know that "manbags" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case manbags = scrota.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SCROTA mean?
SCROTA noun- The bag of skin and muscle that contains the testicles in mammals.