The most common and most likely answer to this crossword clue is the 2 plus 4 letter word ST PAUL
I've seen this crossword clue in Financial Times
S
T
P
A
U
L
More clues leading to the result ST PAUL
- Wayward lass put in religious building
- State capital built up last
- Acts author changed on the road
- Religious artefact in Last Supper only half sculpted
- Christian missionary left America retaining suitable backing
- Letter writer set up Raquel with every other one
- Apostle Saul went around outskirts of township
- Minnesota city street with university crossed by friend
Buddy explains!

The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.