The most common and most likely answer to this crossword clue is the 2 plus 4 letter word IN FACT
I've seen this crossword clue in The Times
I
N
F
A
C
T
More clues leading to the result IN FACT
- Soccer organisation about to block international, actually
- Trendy female performance, to tell the truth
- Actually do something with endless knowledge
- Popular energy source contains drug, actually
- Really popular female turn
- Actually at home, female needs to do something
- Actually starts to increase numbers for all contributing trusts
- . As a matter of reality, it's not quite fine, shoddy work
- Really popular female performance
Buddy explains!

The straight part
We know that "Actually" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case actually = in fact.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.