The most common and most likely answer to this crossword clue is the 6 plus 2 plus 6 letter word WHEELS IN MOTION
I've seen this crossword clue in The Guardian
W
H
E
E
L
S
I
N
M
O
T
I
O
N
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.