The most common and most likely answer to this crossword clue is the 8 letter word AGONISES
I've seen this crossword clue in The Guardian
A
G
O
N
I
S
E
S
More clues leading to the result AGONISES
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does AGONISES mean?
AGONISES verb- To writhe with agony; to suffer violent anguish.
- To struggle; to wrestle; to strive desperately, whether mentally or physically.