Cryptic crossword clue
Affected charm

The most common and most likely answer to this crossword clue is the 7 letter word UNCTION

I've seen this crossword clue in Independent
U
N
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Buddy explains!

The straight part
We know that ", a factor female’s lacking (7)" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case , a factor female’s lacking (7) = unction.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does UNCTION mean?

UNCTION noun
  1. A salve or ointment.
  2. A religious or ceremonial anointing.
  3. A balm or something that soothes.
  4. A quality in language, address or delivery which expresses sober and fervent emotion.
  5. A smug, exaggerated use of language; smarminess.
  6. Divine or sanctifying grace.

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