The most common and most likely answer to this crossword clue is the 10 letter word INFLUENCED
I've seen this crossword clue in The Guardian
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More clues leading to the result INFLUENCED
Buddy explains!

The straight part
We know that "Affected" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case affected = influenced.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does INFLUENCED mean?
INFLUENCED verb- To have an effect on by using gentle or subtle action; to exert an influence upon; to modify, bias, or sway; to persuade or induce.
- To exert, make use of one's influence.
- To cause to flow in or into; infuse; instill.
- Subject to an effect caused by a person or thing outside of the subject's control.