The most common and most likely answer to this crossword clue is the 12 letter word HEARTSTRINGS
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More clues leading to the result HEARTSTRINGS
Buddy explains!

The straight part
We know that "Affections" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case affections = heartstrings.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does HEARTSTRINGS mean?
HEARTSTRINGS noun- The tendons once thought to brace the heart.
- One's deepest emotions or inner feelings.
- The cord-like tendons that connect the papillary muscles to the tricuspid valve and the mitral valve in the heart.