Cryptic crossword clue
Afflicted in place of rest, bad, getting taken in hand 10

The most common and most likely answer to this crossword clue is the 10 letter word BEDEVILLED

I've seen this crossword clue in Independent
B
E
D
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D

Buddy explains!

The straight part
We know that "Afflicted" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case afflicted = bedevilled.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does BEDEVILLED mean?

BEDEVILLED verb
  1. To harass or cause trouble for; to plague.
  2. To perplex or bewilder.

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