Cryptic crossword clue
After party, kiss Yankee’s ancient mistress 4

The most common and most likely answer to this crossword clue is the 4 letter word DOXY

I've seen this crossword clue in The Times
D
O
X
Y

Buddy explains!

The straight part
We know that "ancient mistress" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case ancient mistress = doxy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DOXY mean?

DOXY noun
  1. A sweetheart; a prostitute or a mistress.
DOXY noun
  1. A defined opinion.
DOXY noun
  1. A broad-spectrum antibiotic, C22H24N2O8, of the tetracycline class.
DOXY noun
  1. A dachshund.

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