The most common and most likely answer to this crossword clue is the 10 letter word EMISSARIES
E
M
I
S
S
A
R
I
E
S
More clues leading to the result EMISSARIES
- Ambassadors from Spain fail to spot sign
- Envoys, English, fail to see sign
- Agents placing ewe initially with most beautiful ram?
- Agents from Spain fail to seize house
- More than one agent stars — negligent, not right, to begin with
- Agents inside of jet don’t see sign
- Agents fail to spot sign on back of cape
Buddy explains!

The straight part
We know that "Agents" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case agents = emissaries.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does EMISSARIES mean?
EMISSARIES noun- An agent sent on a mission to represent the interests of someone else.
- A venous channel in the skull.
- An underground channel by which the water of a lake escapes.