Cryptic crossword clue
Agitated blokes in terrible fret end losing heart 9

The most common and most likely answer to this crossword clue is the 9 letter word FERMENTED

I've seen this crossword clue in The Daily Telegraph
F
E
R
M
E
N
T
E
D

Buddy explains!

The straight part
We know that "Agitated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case agitated = fermented.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does FERMENTED mean?

FERMENTED verb
  1. To react, using fermentation; especially to produce alcohol by aging or by allowing yeast to act on sugars; to brew.
  2. To stir up, agitate, cause unrest or excitement in.
FERMENTED adjective
  1. Produced by fermentation.
  2. Of food or drink, turned sour due to unwanted fermentation.

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