Cryptic crossword clue
Agonising trial involving Vogue 12

The most common and most likely answer to this crossword clue is the 12 letter word HEARTRENDING

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Buddy explains!

The straight part
We know that "Agonising" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case agonising = heartrending.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does HEARTRENDING mean?

HEARTRENDING adjective
  1. That causes great grief, anguish or distress.
  2. That elicits deep sympathy.

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