Cryptic crossword clue
Aiming to follow foolish instruction in nursery 5-8

The most common and most likely answer to this crossword clue is the 14 letter word POTTY-TRAINING

I've seen this crossword clue in The Guardian
P
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T
T
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Buddy explains!

The straight part
We know that "instruction in nursery" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case instruction in nursery = potty-training.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does POTTY-TRAINING mean?

POTTY-TRAINING noun
  1. The act of weaning a child off of diapers and teaching them how to use a potty. Not usually distinguished from toilet training although generally children do not use an adult-sized toilet right away.

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