The most common and most likely answer to this crossword clue is the 2 plus 5 letter word ON GUARD
O
N
G
U
A
R
D
More clues leading to the result ON GUARD
- Vigilant Busby’s situation?
- Monitoring substance picked up when American comes in after performing
- Alert, M flees island during rise of 007’s foe
- Doing sentry duty in rocky ground screening west of airport
- Vigilant, rung a crook getting into overdraft
- Vigilant head of army invades foreign ground
- Vigilant amateur breaking new ground
- Vigilant against dog, run a program
Buddy explains!

The straight part
We know that "Alert" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case alert = on guard.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.