Cryptic crossword clue
Alienated duke has an artificial manner 11

The most common and most likely answer to this crossword clue is the 11 letter word DISAFFECTED

I've seen this crossword clue in The Times
D
I
S
A
F
F
E
C
T
E
D

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The straight part
We know that "Alienated" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case alienated = disaffected.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DISAFFECTED mean?

DISAFFECTED verb
  1. To cause a loss of affection, sympathy or loyalty in; to alienate or estrange.
DISAFFECTED adjective
  1. Alienated or estranged, often with hostile effect; rebellious, resentful; disloyal.
  2. Affected with disease.

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