The most common and most likely answer to this crossword clue is the 9 letter word ESTRANGES
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ESTRANGES mean?
ESTRANGES verb- To cause to feel less close or friendly; alienate. To cease contact with (particularly of a family member or spouse, especially in form estranged).
- To remove from an accustomed place or set of associations.