Cryptic crossword clue
All but nullify a monarch that’s gigantic and awfully distant 6

The most common and most likely answer to this crossword clue is the 6 letter word QUASAR

I've seen this crossword clue in The Guardian
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Buddy explains!

The straight part
We know that "that’s gigantic and awfully distant" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case that’s gigantic and awfully distant = quasar.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does QUASAR mean?

QUASAR noun
  1. An extragalactic object, starlike in appearance, that is among the most luminous and (putatively) the most distant objects in the universe.

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