The most common and most likely answer to this crossword clue is the 6 plus 2 plus 4 letter word NOBODY AT HOME
I've seen this crossword clue in The Daily Telegraph
N
O
B
O
D
Y
A
T
H
O
M
E
Buddy explains!
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.