Cryptic crossword clue
All upset about tragic playing, requiring tranquillizer 9

The most common and most likely answer to this crossword clue is the 9 letter word LARGACTIL

L
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L

Buddy explains!

The straight part
We know that "tranquillizer" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case tranquillizer = largactil.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does LARGACTIL mean?

LARGACTIL noun
  1. A synthetic drug used as a tranquillizer, sedative, and antiemetic. It is a phenothiazine derivative.

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