Cryptic crossword clue
Allergic reaction having taken LSD, perhaps: expression of support welcomed

The most common and most likely answer to this crossword clue is the 11 letter word INTOLERANCE

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Buddy explains!

The straight part
We know that "Allergic reaction" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case allergic reaction = intolerance.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does INTOLERANCE mean?

INTOLERANCE noun
  1. The state of being intolerant.
  2. An intolerant word or action.
  3. Extreme sensitivity to a food or drug; allergy.

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