Cryptic crossword clue
Altering stations with redesign of some insides 16

The most common and most likely answer to this crossword clue is the 16 letter word GASTROINTESTINAL

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Buddy explains!

The straight part
We know that "of some insides" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case of some insides = gastrointestinal.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does GASTROINTESTINAL mean?

GASTROINTESTINAL adjective
  1. Of or pertaining to the stomach and intestines, and thus to digestion.

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