Cryptic crossword clue
Always hampering a take-off 5

The most common and most likely answer to this crossword clue is the 5 letter word APERY

A
P
E
R
Y

Buddy explains!

The straight part
We know that "take-off" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case take-off = apery.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does APERY mean?

APERY noun
  1. A place where apes are kept.
  2. The practice of aping; an apish action.

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