Cryptic crossword clue
Always playing music, supreme on the fiddle missing you

The most common and most likely answer to this crossword clue is the 6 letter word SEMPRE

I've seen this crossword clue in The Guardian
S
E
M
P
R
E

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The straight part
We know that "Always playing music" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case always playing music = sempre.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SEMPRE mean?

SEMPRE adverb
  1. (as a qualifier) always, still; maintaining the same style

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