Cryptic crossword clue
Amendment issue can lead to nationwide problems 9

The most common and most likely answer to this crossword clue is the 9 letter word NUISANCES

N
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I
S
A
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S

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does NUISANCES mean?

NUISANCES noun
  1. A minor annoyance or inconvenience.
  2. A person or thing causing annoyance or inconvenience.
  3. Anything harmful or offensive to the community or to a member of it, for which a legal remedy exists.

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