Cryptic crossword clue
American dad left former partner Amy finally in fit of infuriation 8

The most common and most likely answer to this crossword clue is the 8 letter word APOPLEXY

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Buddy explains!

The straight part
We know that "fit of infuriation" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case fit of infuriation = apoplexy.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does APOPLEXY mean?

APOPLEXY noun
  1. Bleeding within internal organs and the accompanying symptoms.
  2. Sudden diminution or loss of consciousness, sensation, and voluntary motion, usually caused by pressure on the brain.
  3. (colloquially) Great anger and excitement.

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