The most common and most likely answer to this crossword clue is the 6 letter word ROOMER
I've seen this crossword clue in Independent
R
O
O
M
E
R
More clues leading to the result ROOMER
Buddy explains!
The straight part
We know that "American lodger" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case american lodger = roomer.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does ROOMER mean?
ROOMER noun- A person who rents a room.
- (in combination) A residence having the specified number of rooms.
- At a greater distance; farther off.