The most common and most likely answer to this crossword clue is the 4 plus 2 letter word USED UP
I've seen this crossword clue in The Daily Telegraph
U
S
E
D
U
P
More clues leading to the result USED UP
- Ran through party on purpose
- Exhausted, American journalist on horseback
- Finished milk dish that’s on the turn
- Exhausted by current Tory tactic to stay in government?
- Spent cash in Irish party
- Exhausted
- Me and my pals with a little 7Up. It’s all gone now
- Pursued frantically, runs away exhausted
- Exhausted, being employed at university
- American political party, being full of energy, got through
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.