Cryptic crossword clue
American Symphony Orchestra in Newark, last of all 4

The most common and most likely answer to this crossword clue is the 4 letter word YANK

I've seen this crossword clue in The Times
Y
A
N
K

Buddy explains!

The straight part
We know that "American" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case american = yank.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does YANK mean?

YANK noun
  1. A sudden, vigorous pull (sometimes defined as mass times jerk, or rate of change of force).
  2. A masturbation session.
YANK verb
  1. To pull (something) with a quick, strong action.
  2. To remove from distribution.
YANK noun
  1. A Yankee.

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