Cryptic crossword clue
American wears top out of bed or stuck in it 4,2

The most common and most likely answer to this crossword clue is the 4 plus 2 letter word LAID UP

I've seen this crossword clue in The Guardian
L
A
I
D
U
P


Buddy explains!

The straight part
We know that "stuck in it" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case stuck in it = laid up.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.


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