Cryptic crossword clue
America’s mischief, awfully sly, left UK bearing new grudge 12

The most common and most likely answer to this crossword clue is the 12 letter word SKULLDUGGERY

I've seen this crossword clue in The Times
S
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Buddy explains!

The straight part
We know that "America’s mischief" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case america’s mischief = skullduggery.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does SKULLDUGGERY mean?

SKULLDUGGERY noun
  1. A devious device or trick.
  2. Dishonest, underhanded, or unscrupulous activities or behaviour.

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