The most common and most likely answer to this crossword clue is the 6 letter word SCREAM
I've seen this crossword clue in The Times
S
C
R
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A
M
More clues leading to the result SCREAM
- Second best way to attract attention?
- Yell “Clear off!”, seizing tablet
- First of six top people? A very funny person
- Yell coming from son given fatty food
- Mayonnaise a lad dropped: that's so funny
- Son has the best yell
- Amusing person makes you laugh uproariously
- Comic that is requiring much paper
- Singular flower, one causing much joy?
- Second best comedian
Buddy explains!

The straight part
We know that "Amusing person/laugh uproariously" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case amusing person/laugh uproariously = scream.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.
What does SCREAM mean?
SCREAM noun- A loud, emphatic, exclamation of extreme emotion, especially horror, fear, excitement, or anger; it may comprise a word or a sustained, high-pitched vowel sound.
- A form of singing associated with the metal and screamo styles of music. It is a loud, rough, distorted version of the voice; rather than the normal voice of the singer.
- Used as an intensifier
- (printers' slang) exclamation mark
- To cry out with a shrill voice; to utter a sudden, sharp outcry, or shrill, loud cry, as in fright or extreme pain; to shriek; to screech.
- To move quickly; to race.
- To be very indicative of; clearly having the characteristics of.