Cryptic crossword clue
Amusing trait strangely causing great distress 12

The most common and most likely answer to this crossword clue is the 12 letter word TRAUMATISING

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Buddy explains!

The straight part
We know that "causing great distress" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case causing great distress = traumatising.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TRAUMATISING mean?

TRAUMATISING verb
  1. To injure, e.g. tissues, by force or by thermal, chemical or other agents.
  2. To cause a trauma in.

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