Cryptic crossword clue
An action that leaves the head isolated 12

The most common and most likely answer to this crossword clue is the 12 letter word DECAPITATION

I've seen this crossword clue in The Daily Telegraph
D
E
C
A
P
I
T
A
T
I
O
N

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does DECAPITATION mean?

DECAPITATION noun
  1. Beheading; the act of beheading or decapitating
  2. The ousting or destruction of the ruling body of a government or other organization.
  3. The unseating of a senior politician.

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