Cryptic crossword clue
An amount of poison directed at team, Guardiola’s team 8

The most common and most likely answer to this crossword clue is the 8 letter word TOXICITY

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "An amount of poison" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case an amount of poison = toxicity.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does TOXICITY mean?

TOXICITY noun
  1. The quality or degree of being toxic.

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