The most common and most likely answer to this crossword clue is the 3 plus 3 letter word AND HOW
I've seen this crossword clue in Financial Times
A
N
D
H
O
W
More clues leading to the result AND HOW
- Hand damaged: that hurts, exceedingly
- Small son that produces show? You bet!
- An Arabian vessel? Yes indeed
- Certainly an exotic craft
- An Arabic vessel? I’ll say!
- . Article taken by boat? I should think so
- One to a boat? I should think so indeed
- A new vessel? I should think so, indeed!
- So much for Mandy, not heeding my unending scream!
- A navy vessel? You bet!
Buddy explains!

The straight part
We know that "I’ll say!" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case i’ll say! = and how.The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.