Cryptic crossword clue
An old ambition crushed can be a terrible thing

The most common and most likely answer to this crossword clue is the 11 letter word ABOMINATION

I've seen this crossword clue in Independent
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Buddy explains!

The straight part
We know that "terrible thing" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case terrible thing = abomination.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ABOMINATION mean?

ABOMINATION noun
  1. An abominable act; a disgusting vice; a despicable habit.
  2. The feeling of extreme disgust and hatred
  3. A state that excites detestation or abhorrence; pollution.
  4. That which is abominable, shamefully vile; an object that excites disgust and hatred; very often with religious undertones.

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