Cryptic crossword clue
An old king with uplifting first-class medical condition 8

The most common and most likely answer to this crossword clue is the 8 letter word ANOREXIA

I've seen this crossword clue in The Daily Telegraph
A
N
O
R
E
X
I
A

Buddy explains!

The straight part
We know that "medical condition" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case medical condition = anorexia.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANOREXIA mean?

ANOREXIA noun
  1. Loss of appetite, especially as a result of disease.
  2. Anorexia nervosa.

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