Cryptic crossword clue
An old lady’s to cackle about odd stuff 10

The most common and most likely answer to this crossword clue is the 10 letter word ANTIMATTER

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The cryptic/wordplay part
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This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does ANTIMATTER mean?

ANTIMATTER noun
  1. Matter that is composed of the antiparticles of those that constitute normal matter.
  2. A form of matter that has a key property, such as charge, opposite to that of ordinary matter.

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