Cryptic crossword clue
Analyse change of ‘main’ to ‘sea’ 9

The most common and most likely answer to this crossword clue is the 9 letter word ANATOMISE

I've seen this crossword clue in Independent
A
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Buddy explains!

The straight part
We know that "analyse" is the straight/definition part of the clue. The straight part is often a synonym or definition, in this case analyse = anatomise.
The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does ANATOMISE mean?

ANATOMISE verb
  1. To inspect or investigate by dissection.
  2. To scrutinize down to the most minute detail.

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