Cryptic crossword clue
Ancient city on eastern river 3

The most common and most likely answer to this crossword clue is the 3 letter word URE

I've seen this crossword clue in The Times
U
R
E

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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.
This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
Sadly, We don't have an explanation for this specific crossword clue yet.

What does URE mean?

URE noun
  1. (only in collocations in ure, out of ure) use, practise, exercise.
URE verb
  1. To use; to exercise; to inure; to accustom by practice.

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