The most common and most likely answer to this crossword clue is the 6 letter word COYPUS
I've seen this crossword clue in Independent
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More clues leading to the result COYPUS
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The cryptic/wordplay part
In cryptic crossword there's often an wordplay/cryptic part as well.This part involves a more complex hint, such as an anagram, homophone, hidden word, etc.
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What does COYPUS mean?
COYPUS noun- A large, crepuscular, semiaquatic rodent (Myocastor coypus) resembling a large rat, having bright orange-yellow incisors, native to South America and introduced to Europe, Asia and North America, valued for its fur in eastern Europe and central Asia and considered a pest elsewhere.